Star Trek: Deep Space 9, Enterprise, Voyager - Re-Animator - Babylon 5
Combs's best-known horror role is Herbert West, the main character in the film Re-Animator, and its two sequels. He portrayed author H. P. Lovecraft (creator of the Herbert West character) in the film Necronomicon: Book of the Dead (1993) and has starred in eight H.P. Lovecraft adaptations. Other film credits include The Attic Expeditions (2001), FeardotCom (2002), House on Haunted Hill (1999), I Still Know What You Did Last Summer(1998), and The Frighteners (1996).
Combs has had roles in many science fiction television series. He starred as the telepath Harriman Gray in first-season episode "Eyes" (1994) of Babylon 5. In 2001, he played the sinister Dr. Ek in The Attic Expeditions. In August 2005, he appeared for the first time on the science fiction series The 4400 as Dr. Kevin Burkhoff which had become a recurring role by 2006. In early 2007, he played a highly fictionalized Edgar Allan Poe in "The Black Cat" episode of Masters of Horror.
Combs has worked extensively as a voiceover artist. His voiceover roles include the Scarecrow in The New Batman Adventures, the Question in Justice League Unlimited, Ratchet in Transformers: Prime, the Leader in The Avengers: Earth's Mightiest Heroes, the Rat King in Teenage Mutant Ninja Turtles and Brainiac in Injustice 2. He also narrated the 25th Anniversary of Re-Animator at the 2010 FanTasia.
In July 2009, Combs returned to his stage roots and reprised his role as Edgar Allan Poe in a one-man theatrical show entitled Nevermore...an Evening with Edgar Allan Poe at The Steve Allen Theater in Hollywood, CA. Although only supposed to run for a month, the show enjoyed much success and sold-out crowds and was extended four times. Nevermore as it is now simply known, closed its run in Los Angeles on December 19, 2009. The show had its East Coast debut on 23 and 24 January 2010 at Westminster Hall in Baltimore, MD, Poe's final resting place. A tour of the Saturn Award-nominated Nevermore is now in the works, with stops possibly including Chicago, New York, and Seattle, and a confirmed two-date run in San Diego in February.
Combs starred with Andrew Divoff in the 2012 Screen Media Films release Night of the Living Dead 3D: Re-Animation, a prequel to the 2006 cult hit Night of the Living Dead 3D directed by Jeff Broadstreet. In 2012, he also played Dr. Lambrick in Would You Rather.
On television, Combs enjoyed popular success playing a number of alien characters on the various modern Star Trek incarnations, beginning with Star Trek: Deep Space Nine in 1994, with Star Trek: Voyager in 2000, and with Star Trek: Enterprise in 2001. Combs has played nine different onscreen roles in the Star Trek universe. His largest science-fiction role to date was his regular guest role on Deep Space Nine as the Vorta clone Weyoun. Combs has said that Weyoun was his favorite Star Trek role, and he had a great deal of input in developing the character.
On the same series, Combs had a recurring role as the Ferengi character Brunt. During the DS9 episode "The Dogs of War", Combs appeared as both Weyoun and Brunt, making Star Trek history as the first actor to play two unrelated recurring roles on screen in the same episode; however, the two characters never appeared in the same scene together.
On Enterprise, Combs had a recurring role as Shran, an Andorian military officer. Enterprise producer Manny Coto once mentioned in an interview hoping to make Combs a regular on Enterprise had the series been renewed for a fifth season.
In addition to his recurring Star Trek roles, Combs had non-recurring roles as a human police officer Kevin Mulkahey, as the alien Tiron on Deep Space Nine; as the alien Penk on Voyager; and as the Ferengi pirate Krem on Enterprise. Along with many other actors, writers, and creators of the show, Combs also had a cameo appearance as a holographic patron in Vic's Lounge in the final episode of Deep Space Nine. Combs also voices the character of Romulan Commander Suldok for the Star Trek: Elite Force II video game.